Methadone continues to be a widely used maintenance therapy for opiate dependence.
However, methadone-related deaths have been reported frequently for over 4 decades now.
Anoxic brain injury with pulmonary edema secondary to respiratory depression is the
recognized mechanism of methadone death, although pathological intracranial findings are
rarely described in methadone deaths. A selective area of brain injury has never been
reported with methadone use. We present a case of a 23-year-old man who had acute …