Biologically active branched polysaccharide mimetics: Synthesis via ring-opening polymerization of a maltose-based β-lactam
ACS Macro Letters, 2018•ACS Publications
Stereoregular poly-amido-saccharides bearing α-glucopyranose branches (Mal-PASs) are
synthesized by anionic ring-opening polymerization of a maltose-based β-lactam monomer
followed by debenzylation. The polymerization affords high molecular weight polymers (up
to 31500 g/mol) with narrow dispersities (Đ< 1.1). Deprotected Mal-PASs are highly soluble
in water and adopt a left-handed helical conformation in solution. Turbidimetric assay shows
that Mal-PASs are multivalent ligands to lectin Concanavalin A.
synthesized by anionic ring-opening polymerization of a maltose-based β-lactam monomer
followed by debenzylation. The polymerization affords high molecular weight polymers (up
to 31500 g/mol) with narrow dispersities (Đ< 1.1). Deprotected Mal-PASs are highly soluble
in water and adopt a left-handed helical conformation in solution. Turbidimetric assay shows
that Mal-PASs are multivalent ligands to lectin Concanavalin A.
Stereoregular poly-amido-saccharides bearing α-glucopyranose branches (Mal-PASs) are synthesized by anionic ring-opening polymerization of a maltose-based β-lactam monomer followed by debenzylation. The polymerization affords high molecular weight polymers (up to 31500 g/mol) with narrow dispersities (Đ < 1.1). Deprotected Mal-PASs are highly soluble in water and adopt a left-handed helical conformation in solution. Turbidimetric assay shows that Mal-PASs are multivalent ligands to lectin Concanavalin A.
ACS Publications以上显示的是最相近的搜索结果。 查看全部搜索结果