Bladder instillations vs onabotulinumtoxinA injection for interstitial cystitis/bladder pain syndrome: a randomized clinical trial
EK Welch, KL Dengler, AM DiCarlo-Meacham… - American journal of …, 2024 - Elsevier
Background Interstitial cystitis (IC)/bladder pain syndrome (BPS) is an unpleasant sensation
related to the bladder with lower urinary tract symptoms lasting more than 6 weeks,
unrelated to an otherwise identifiable cause. The etiology is likely multifactorial including
urothelial abnormalities, neurogenic pain upregulation, and potentially bladder and vaginal
microbiome alterations. Despite treatment effectiveness of both bladder instillations and
intradetrusor onabotulinumtoxinA injection for this condition, a head-to-head comparison …
related to the bladder with lower urinary tract symptoms lasting more than 6 weeks,
unrelated to an otherwise identifiable cause. The etiology is likely multifactorial including
urothelial abnormalities, neurogenic pain upregulation, and potentially bladder and vaginal
microbiome alterations. Despite treatment effectiveness of both bladder instillations and
intradetrusor onabotulinumtoxinA injection for this condition, a head-to-head comparison …
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