As unforeseen situations, emergencies threaten the environment, property, and people’s lives. Large emergencies are characterized by the demand for coordination of a variety of actors, such as civil defense or disaster relief. Communication and information exchange are crucial for coordination. Therefore, a solid, stable communication infrastructure is among the crucial factors for emergency response. New technologies that seem to ensure trustworthy communication must be evaluated constantly. Blockchain technology is widely applied in a broad variety of contexts and is commonly known for its decentralized and distributed governance. This is the motivation for the design and evaluation of a framework for the adoption of blockchain technology in the case of emergency response following a design science approach. Evaluation of the artifact using a specific evaluation framework clearly indicates the suitability of the case for application of blockchain technology.