Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma
MC Tai, K Yanagisawa, M Nakatochi, N Hotta… - Scientific reports, 2016 - nature.com
Accumulated evidence indicates that various types of miRNA are aberrantly expressed in
lung cancer and secreted into the bloodstream. For this study, we constructed a serum
diagnostic classifier based on detailed bioinformatics analysis of miRNA profiles from a
training cohort of 143 lung adenocarcinoma patients and 49 healthy subjects, resulting in a
20 miRNA-based classifier. Validation performed with an independent cohort of samples
from lung adenocarcinoma patients (n= 110), healthy subjects (n= 52) and benign …
lung cancer and secreted into the bloodstream. For this study, we constructed a serum
diagnostic classifier based on detailed bioinformatics analysis of miRNA profiles from a
training cohort of 143 lung adenocarcinoma patients and 49 healthy subjects, resulting in a
20 miRNA-based classifier. Validation performed with an independent cohort of samples
from lung adenocarcinoma patients (n= 110), healthy subjects (n= 52) and benign …
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