Mesenchymal stem cells (MSCs) have been recently shown to inhibit T-cell proliferation to
polyclonal stimuli. We characterized the effect of MSCs of bone marrow origin on the T-cell
response of naive and memory T cells to their cognate antigenic epitopes. The immune
response to murine male transplantation antigens, HY, was selected because the peptide
identity and major histocompatibility complex (MHC) restriction of the immunodominant
epitopes are known. C57BL/6 female mice immunized with male cells were the source of …

Mesenchymal stem cells (MSC) have been recently shown to inhibit T-cell proliferation to
polyclonal stimuli. We characterized the effect of MSC of bone marrow origin on the T-cell
response of naïve and memory T cells to their cognate antigenic epitopes. The immune
response to murine male transplantation antigens, HY, was selected because the peptide
identity and MHC restriction of the immunodominant epitopes are known. C57BL/6 female
mice immunized with male cells were the source of memory T cells, whereas C6 mice …