Bone morphogenetic protein-9 is a circulating vascular quiescence factor
L David, C Mallet, M Keramidas, N Lamandé… - Circulation …, 2008 - Am Heart Assoc
Angiogenesis is a complex process, requiring a finely tuned balance between numerous
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial-
specific type 1 receptor of the transforming growth factor-β receptor family. Heterozygotes
with mutations in the ALK1 gene develop hereditary hemorrhagic telangiectasia type 2
(HHT2). Recently, we reported that bone morphogenetic protein (BMP) 9 and BMP10 are
specific ligands for ALK1 that potently inhibit microvascular endothelial cell migration and …
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial-
specific type 1 receptor of the transforming growth factor-β receptor family. Heterozygotes
with mutations in the ALK1 gene develop hereditary hemorrhagic telangiectasia type 2
(HHT2). Recently, we reported that bone morphogenetic protein (BMP) 9 and BMP10 are
specific ligands for ALK1 that potently inhibit microvascular endothelial cell migration and …
Bone morphogenetic protein-9 is a circulating vascular quiescence factor.: BMP9 is present in serum and inhibits angiogenesis
L David, C Mallet, M Keramidas, N Lamandé, JM Gasc… - 2008 - policycommons.net
Angiogenesis is a complex process, requiring a finely tuned balance between numerous
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial-
specific type 1 receptor of the transforming growth factor-beta receptor family. Heterozygotes
with mutations in the ALK1 gene develop hereditary hemorrhagic telangiectasia type 2
(HHT2). Recently, we reported that bone morphogenetic protein (BMP) 9 and BMP10 are
specific ligands for ALK1 that potently inhibit microvascular endothelial cell migration and …
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial-
specific type 1 receptor of the transforming growth factor-beta receptor family. Heterozygotes
with mutations in the ALK1 gene develop hereditary hemorrhagic telangiectasia type 2
(HHT2). Recently, we reported that bone morphogenetic protein (BMP) 9 and BMP10 are
specific ligands for ALK1 that potently inhibit microvascular endothelial cell migration and …
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