[HTML][HTML] Both oleanolic acid and a mixture of oleanolic and ursolic acids mimic the effects of fructus ligustri lucidi on bone properties and circulating 1, 25 …
S Cao, ME Wastney, PJ Lachcik, HH Xiao… - The Journal of …, 2018 - Elsevier
Background Oleanolic acid (OA) and ursolic acid (UA) are major chemical constituents
found in Fructus ligustri lucidi (FLL), a Chinese herb previously shown to increase bone
properties and modulate calcium-vitamin D metabolism in rats. OA and UA have been
reported to exert osteoprotective effects in vitro. Objective The present study was designed
to determine whether OA or OA+ UA mimicked the effects of FLL on bone and calcium
homeostasis using ovariectomized rats. Methods Three-month-old ovariectomized Sprague …
found in Fructus ligustri lucidi (FLL), a Chinese herb previously shown to increase bone
properties and modulate calcium-vitamin D metabolism in rats. OA and UA have been
reported to exert osteoprotective effects in vitro. Objective The present study was designed
to determine whether OA or OA+ UA mimicked the effects of FLL on bone and calcium
homeostasis using ovariectomized rats. Methods Three-month-old ovariectomized Sprague …