The Nuclear receptor 1 family I member 3 (NR1I3), also known as the Constitutive
Androstane Receptor (CAR), was initially characterized as a key regulator of xenobiotic
metabolism. However, recent biochemical and structural data suggest that NR1I3 is
activated in response to metabolic and nutritional stress in a ligand-independent manner.
Thus, we prospected the Bovine NR1I3 gene for polymorphisms and studied their
association with feed efficiency traits in Nellore cattle. First, 155 purebred Nellore bulls were …