Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide
GW Zhang, DH Zheng, J Nie, T Wang… - Organic & biomolecular …, 2010 - pubs.rsc.org
GW Zhang, DH Zheng, J Nie, T Wang, JA Ma
Organic & biomolecular chemistry, 2010•pubs.rsc.orgA general method for the one-pot, three-component Strecker reaction of ketones was
developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were
obtained in good to excellent yields (79–99%). A preliminary extension to a catalytic
enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also
described.
developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were
obtained in good to excellent yields (79–99%). A preliminary extension to a catalytic
enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also
described.
A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79–99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.
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