Brain antioxidant responses to acute iron and copper intoxications in rats
J Semprine, N Ferrarotti, R Musacco-Sebio… - Metallomics, 2014 - academic.oup.com
Dose-and time-dependent antioxidant responses to Fe (0–60 mg kg− 1) and Cu overloads
(0–30 mg kg− 1) in rat brains are described by the C 50 and the t 1/2, the brain metal
concentration and the time for half maximal oxidative responses. Brain GSH and the
GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with at 1/2 of 9–
10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most
sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo …
(0–30 mg kg− 1) in rat brains are described by the C 50 and the t 1/2, the brain metal
concentration and the time for half maximal oxidative responses. Brain GSH and the
GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with at 1/2 of 9–
10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most
sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo …
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