ageing, we sought to investigate the associations between cardio-vascular risk, mental
health, cognitive performance and brain anatomy in mid-to old age. We analyzed a set of
risk factors together with multi-parameter magnetic resonance imaging (MRI) in the CoLaus|
PsyCoLaus cohort (n> 1200). Cardio-vascular risk was associated with differences in brain
tissue properties–myelin, free tissue water, iron content–and regional brain volumes that we …