Breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer
I Balgkouranidou, M Chimonidou, G Milaki… - British journal of …, 2014 - nature.com
Background: Breast-cancer metastasis suppressor 1 (BRMS1) gene encodes for a
predominantly nuclear protein that differentially regulates the expression of multiple genes,
leading to suppression of metastasis without blocking orthotropic tumour growth. The aim of
the present study was to evaluate for the first time the prognostic significance of BRMS1
promoter methylation in cell-free DNA (cfDNA) circulating in plasma of non-small cell lung
cancer (NSCLC) patients. Towards this goal, we examined the methylation status of BRMS1 …
predominantly nuclear protein that differentially regulates the expression of multiple genes,
leading to suppression of metastasis without blocking orthotropic tumour growth. The aim of
the present study was to evaluate for the first time the prognostic significance of BRMS1
promoter methylation in cell-free DNA (cfDNA) circulating in plasma of non-small cell lung
cancer (NSCLC) patients. Towards this goal, we examined the methylation status of BRMS1 …
Breast cancer metastasis suppressor-1 promoter methylation in cell free DNA provides prognostic information in non-small cell lung cancer
I Balkouranidou, M Chimonidou, G Milaki, E Tsaroucha… - Cancer Research, 2014 - AACR
Background: Breast-cancer metastasis suppressor 1 (BRMS1) gene encodes for a
predominantly nuclear protein that differentially regulates the expression of multiple genes,
leading to suppression of metastasis without blocking orthotopic tumor growth. The aim of
the present study was to evaluate for the first time the prognostic significance of BRMS1
promoter methylation in cell free DNA (cfDNA) circulating in plasma of non-small cell lung
cancer (NSCLC) patients. Towards this goal, we examined the methylation status of BRMS1 …
predominantly nuclear protein that differentially regulates the expression of multiple genes,
leading to suppression of metastasis without blocking orthotopic tumor growth. The aim of
the present study was to evaluate for the first time the prognostic significance of BRMS1
promoter methylation in cell free DNA (cfDNA) circulating in plasma of non-small cell lung
cancer (NSCLC) patients. Towards this goal, we examined the methylation status of BRMS1 …
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