We propose a low cost modeling approach to screen the impact of aptamer structural
modifications on their biomechanical stability. This responds to the current immature control
of aptamer properties when integrated into bio-hybrid devices. We predict that common
spacers (PEG, polythymine) disrupt aptamer rigidity, whereas alkyl chains have minimal
incidence on its mechanical properties. We also observe that mutations in the active site are
equally perturbative as PEG or polythymine. We suggest that the rational design of aptamer …