Use of the Saccharomyces cerevisiae as a biosorbent material has proven versatile in innovative applications like the biosorption of bioactive compounds from plant extracts. The bioactive compounds have different biological activities such antioxidant, antimicrobial and anticancer properties. Thus, the application of S. cerevisiae intends to increase the bioaccessibility of bioactive compounds, increasing absorption by the body compared to direct ingestion. The increase in the bioaccessibility of the bioactive compounds occurs by the protection provided by the yeast cell, reducing the degradation that occurs through the action of digestive enzymes and abrupt changes in pH. This review discusses existing adsorption studies using S. cerevisiae biomass, highlighting its use for the biosorption of bioactive compounds, limitations as well as factors that promote an improvement of the biosorptive capacity and bioaccessibility, the main existing applications and future suggestions.