Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration
CYK Zhang, M Ahmed, E Huszti, L Levy… - The Journal of Heart and …, 2020 - Elsevier
BACKGROUND Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung
allograft dysfunction. Bile acids—putative markers of gastric microaspiration—and
inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with
chronic lung allograft dysfunction, but their relationship with GERD remains unclear.
Although GERD is thought to drive chronic microaspiration, the selection of patients for anti-
reflux surgery lacks precision. This multicenter study aimed to test the association of BAL …
allograft dysfunction. Bile acids—putative markers of gastric microaspiration—and
inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with
chronic lung allograft dysfunction, but their relationship with GERD remains unclear.
Although GERD is thought to drive chronic microaspiration, the selection of patients for anti-
reflux surgery lacks precision. This multicenter study aimed to test the association of BAL …
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