Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice
L Shi, Y Li, X Xu, Y Cheng, B Meng, J Xu, L Xiang… - Nature …, 2022 - nature.com
Brown adipose tissue (BAT) activity contributes to cardiovascular health by its energy-
dissipating capacity but how BAT modulates vascular function and atherosclerosis through
endocrine mechanisms remains poorly understood. Here we show that BAT-derived
neuregulin-4 (Nrg4) ameliorates atherosclerosis in mice. BAT-specific Nrg4 deficiency
accelerates vascular inflammation and adhesion responses, endothelial dysfunction and
apoptosis and atherosclerosis in male mice. BAT-specific Nrg4 restoration alleviates …
dissipating capacity but how BAT modulates vascular function and atherosclerosis through
endocrine mechanisms remains poorly understood. Here we show that BAT-derived
neuregulin-4 (Nrg4) ameliorates atherosclerosis in mice. BAT-specific Nrg4 deficiency
accelerates vascular inflammation and adhesion responses, endothelial dysfunction and
apoptosis and atherosclerosis in male mice. BAT-specific Nrg4 restoration alleviates …
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