Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells

AWL Chua, HS Hay, P Rajendran… - Biochemical …, 2010 - Elsevier
… that butein may modulate the expression of CXCR4 and … , that butein can downregulate
CXCR4 expression in various … , through suppression of NF-κB activation. We also found that …

Potential of butein, a tetrahydroxychalcone to obliterate cancer

G Padmavathi, SR Rathnakaram, J Monisha… - Phytomedicine, 2015 - Elsevier
Butein has shown to downregulate p65, an important subtype of NF-κB, thereby inhibiting …
It also suppressed the expression of CXC chemokine receptor-4 (CXCR4) gene by …

Butein in health and disease: A comprehensive review

G Padmavathi, NK Roy, D Bordoloi, F Arfuso, S Mishra… - Phytomedicine, 2017 - Elsevier
… CXC chemokine receptor-4 … II (FAS-II) enzyme and suppressed the growth of Mycobacterium
bovis BCG and M… through the downregulation of PPARγ, LPL, aP2, and C/EBPα levels, and …

Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives

HS Tuli, R Joshi, D Aggarwal, G Kaur, J Kaur… - Chemico-Biological …, 2021 - Elsevier
… CXC chemokine receptor 4 (CXCR4) as an upstream target of butein, which suppresses NF-…
of cancer cells which inhibits migration and metastasis via downregulation of VEGF, MMP9 …

Molecular chemotherapeutic potential of butein: A concise review

RGPT Jayasooriya, IMN Molagoda, C Park… - Food and Chemical …, 2018 - Elsevier
Butein prevents the dissociation of IκB from NF-κB by … suggests that butein suppresses
molecules upstream of IκB and finally … mechanism by which butein downregulated the metastasis …

The inhibitory effects of butein on cell proliferation and TNF-α-induced CCL2 release in racially different triple negative breast cancer cells

P Mendonca, A Horton, D Bauer, S Messeha… - PLoS …, 2019 - journals.plos.org
… , butein downregulated both protein and mRNA expression of … demonstrates butein potential
in cancer cell suppression … reveals the butein inhibitory effect on CCL2 expression with …

[HTML][HTML] Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression

SD Lee, JW Choe, BJ Lee, MH Kang… - World Journal of …, 2015 - ncbi.nlm.nih.gov
… interfere with tumorigenesis through suppression of the inflammatory … to suppress tumor
cell proliferation and angiogenesis[14-18]. One in vitro study demonstrated that butein inhibits

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

KA Manu, MK Shanmugam, P Rajendran, F Li… - Molecular cancer, 2011 - Springer
… Our results clearly indicate that plumbagin suppressed CXCR4 expression in both HER2-lacking
and -overexpressing breast cancer cells, but had minimal effect on HER2 …

Butein inhibits metastatic behavior in mouse melanoma cells through VEGF expression and translation-dependent signaling pathway regulation

YW Lai, SW Wang, CH Chang, SC Liu, YJ Chen… - … and alternative medicine, 2015 - Springer
… was found to inhibit mTOR activation, we hypothesize that butein may suppress VEGF gene
expression in B16F10 cells. Previous studies have reported that aggressive melanoma cell …

Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial cells via inhibition of reactive oxygen …

JH Jang, ES Yang, KJ Min… - … journal of molecular …, 2012 - spandidos-publications.com
butein inhibits the expression of CXC chemokine receptor-4 (… that butein inhibits NF-κB
activation through the suppression … and function through suppression of NF-kappaB activation in …