… RELA, the principal effector of canonical NF-κB signalling, in human cancer. Furthermore, we
show that C11orf95 is … disrupting the cell trafficking of RELA and other partner transcription …

… Neural stem cells transduced with RELA FUS ex vivo form ependymomas when … NF-κB
signaling, suggesting that this aberrant signal is the principal mechanism of oncogenesis. …

… Furthermore, expression of wild type RELA or activating RELA … of non-NF-κB pathways in the
RELA FUS -driven ependymoma … of NF-κB target genes via binding to the NF-κB consensus …

… /p65 subunit of the central NF-κB complex [25, 26]. … C11orf95-RELA fusion encoded RelA
translocates spontaneously to the nucleus even at reduced levels to activate NFKB signalling [8…

… of RELA (RELAFUS1). EPs carrying the C11ORF95-RELA fusion are characterized by a …
accumulation of p65RelA indicating a pathologic activation of the NFκB signaling pathway. …

… Positive RELA-fusion tumors are characterized by the nuclear accumulation of p65/RELA,
which drives oncogenic transformation through NF-κB cell signaling [2, 15, 16]. This …

… in supratentorial ependymomas that results in constitutive aberrant activation of the nuclear
factor-kB (NF-κB) signaling pathway [4]. Several different C11orf95–RELA fusion transcripts …

… ) ependymomas as translocations of the C11orf95 gene of … by which C11orf95RELA
translocations function as fusion onco-… RELA as a potent transcriptional activator of NF-κB …

… that C11orf95-RELA ependymoma is driven by the RELA component of the fusion, binding
affinity of the fusion … localization of RELA is dependent on NF-κB activation, C11orf95-RELA …

… RELA fusion-positive ependymoma. We provide the advanced MR imaging characteristics of
RELA fusion-positive ependymoma… C11orf95–RELA fusion has been detected and appears …