CCR5 Δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis
F Sellebjerg, HO Madsen, CV Jensen, J Jensen… - Journal of …, 2000 - Elsevier
Chemokines and matrix metalloproteinases (MMPs) appear to be crucial in leukocyte
recruitment to the central nervous system in multiple sclerosis (MS). CCR5 Δ32, a truncated
allele of the CC chemokine receptor CCR5 gene encoding a non-functional receptor, did not
confer protection from MS. CCR5 Δ32 was, however, associated with a lower risk of
recurrent clinical disease activity. High CSF levels of MMP-9 activity were also associated
with recurrent disease activity. These results directly link intrathecal inflammation to disease …
recruitment to the central nervous system in multiple sclerosis (MS). CCR5 Δ32, a truncated
allele of the CC chemokine receptor CCR5 gene encoding a non-functional receptor, did not
confer protection from MS. CCR5 Δ32 was, however, associated with a lower risk of
recurrent clinical disease activity. High CSF levels of MMP-9 activity were also associated
with recurrent disease activity. These results directly link intrathecal inflammation to disease …
以上显示的是最相近的搜索结果。 查看全部搜索结果