CD161 contributes to prenatal immune suppression of IFN-γ–producing PLZF+ T cells
J Halkias, E Rackaityte, SL Hillman… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND While the human fetal immune system defaults to a program of tolerance,
there is a concurrent need for protective immunity to meet the antigenic challenges
encountered after birth. Activation of T cells in utero is associated with the fetal inflammatory
response, with broad implications for the health of the fetus and of the pregnancy. However,
the characteristics of the fetal effector T cells that contribute to this process are largely
unknown. METHODS We analyzed primary human fetal lymphoid and mucosal tissues and …
there is a concurrent need for protective immunity to meet the antigenic challenges
encountered after birth. Activation of T cells in utero is associated with the fetal inflammatory
response, with broad implications for the health of the fetus and of the pregnancy. However,
the characteristics of the fetal effector T cells that contribute to this process are largely
unknown. METHODS We analyzed primary human fetal lymphoid and mucosal tissues and …
[PDF][PDF] CD161 contributes to prenatal immune suppression of IFNg-producing PLZF T cells
J Halkias, TC MacKenzie, TD Burt - researchgate.net
Background: While the human fetal immune system defaults to a program of tolerance, there
is concurrent need for protective immunity to meet the antigenic challenges encountered
after birth. Activation of T cells in utero is associated with the fetal inflammatory response
with broad implications for the health of the fetus and of the pregnancy. However, the
characteristics of the fetal effector T cells that contribute to this process are largely unknown.
Methods: We analyzed primary human fetal lymphoid and mucosal tissues and performed …
is concurrent need for protective immunity to meet the antigenic challenges encountered
after birth. Activation of T cells in utero is associated with the fetal inflammatory response
with broad implications for the health of the fetus and of the pregnancy. However, the
characteristics of the fetal effector T cells that contribute to this process are largely unknown.
Methods: We analyzed primary human fetal lymphoid and mucosal tissues and performed …
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