CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational …
Background In patients with HIV, immune reconstitution after antiretroviral therapy (ART) is
often incomplete. We assessed the probability of patients reaching a CD4/CD8 ratio of 1 or
more after the start of ART and its association with the onset of non-AIDS-defining events
and death. Methods We did an analysis of the ICONA cohort, which recruited treatment-
naive patients with HIV in Italy. We included participants in the cohort who started ART,
reached an undetectable viral load (≤ 80 copies per mL), and had a CD4/CD8 ratio of less …
often incomplete. We assessed the probability of patients reaching a CD4/CD8 ratio of 1 or
more after the start of ART and its association with the onset of non-AIDS-defining events
and death. Methods We did an analysis of the ICONA cohort, which recruited treatment-
naive patients with HIV in Italy. We included participants in the cohort who started ART,
reached an undetectable viral load (≤ 80 copies per mL), and had a CD4/CD8 ratio of less …
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