CD47 augments Fas/CD95-mediated apoptosis
PP Manna, J Dimitry, PA Oldenborg… - Journal of Biological …, 2005 - ASBMB
Fas (CD95) mediates apoptosis of many cell types, but the susceptibility of cells to killing by
Fas ligand and anti-Fas antibodies is highly variable. Jurkat T cells lacking CD47 (integrin-
associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by
Fas ligand or anti-Fas IgM (CH11) upon expression of CD47. Lack of CD47 impairs events
downstream of Fas activation including caspase activation, poly-(ADP-ribose) polymerase
cleavage, cytochrome c release from mitochondria, loss of mitochondrial membrane …
Fas ligand and anti-Fas antibodies is highly variable. Jurkat T cells lacking CD47 (integrin-
associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by
Fas ligand or anti-Fas IgM (CH11) upon expression of CD47. Lack of CD47 impairs events
downstream of Fas activation including caspase activation, poly-(ADP-ribose) polymerase
cleavage, cytochrome c release from mitochondria, loss of mitochondrial membrane …
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