Abstract Objective Islets of Langerhans contain heterogeneous populations of insulin-
producing β-cells. Surface markers and respective antibodies for isolation, tracking, and
analysis are urgently needed to study β-cell heterogeneity and explore the mechanisms to
harness the regenerative potential of immature β-cells. Methods We performed single-cell
mRNA profiling of early postnatal mouse islets and re-analyzed several single-cell mRNA
sequencing datasets from mouse and human pancreas and islets. We used mouse primary …