CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells
R García, C Falduti, M Clauzure, R Jara… - … International Journal of …, 2021 - Elsevier
The impairment of the CFTR channel activity, a cAMP-activated chloride (Cl−) channel
responsible for cystic fibrosis (CF), has been associated with a variety of mitochondrial
alterations such as modified gene expression, impairment in oxidative phosphorylation,
increased reactive oxygen species (ROS), and a disbalance in calcium homeostasis. The
mechanisms by which these processes occur in CF are not fully understood. Previously, we
demonstrated a reduced MTND4 expression and a failure in the mitochondrial complex I …
responsible for cystic fibrosis (CF), has been associated with a variety of mitochondrial
alterations such as modified gene expression, impairment in oxidative phosphorylation,
increased reactive oxygen species (ROS), and a disbalance in calcium homeostasis. The
mechanisms by which these processes occur in CF are not fully understood. Previously, we
demonstrated a reduced MTND4 expression and a failure in the mitochondrial complex I …
CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells
R García Solcá, C Falduti, M Clauzure, R Jara… - 2021 - repositorio.uca.edu.ar
The impairment of the CFTR channel activity, a cAMP-activated chloride (Cl−) channel
responsible for cystic fibrosis (CF), has been associated with a variety of mitochondrial
alterations such as modified gene expression, impairment in oxidative phosphorylation,
increased reactive oxygen species (ROS), and a disbalance in calcium homeostasis. The
mechanisms by which these processes occur in CF are not fully understood. Previously, we
demonstrated a reduced MTND4 expression and a failure in the mitochondrial complex I …
responsible for cystic fibrosis (CF), has been associated with a variety of mitochondrial
alterations such as modified gene expression, impairment in oxidative phosphorylation,
increased reactive oxygen species (ROS), and a disbalance in calcium homeostasis. The
mechanisms by which these processes occur in CF are not fully understood. Previously, we
demonstrated a reduced MTND4 expression and a failure in the mitochondrial complex I …
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