COVID-19 infection and circulating ACE2 levels: protective role in women and children
It has been reported that angiotensin-converting enzyme 2 (ACE2) is the main host cell
receptor of human pathogenic coronaviruses [severe acute respiratory syndrome
coronavirus (SARS-CoV), HCoV-NL63, and SARSCoV-2 (COVID-19)], and it plays a crucial
role in the entry of virus into the cell to cause the final infection (1). Wrapp and colleagues
recently provided the Cryo-EM structure of the virus spike protein, the known ligand for
ACE2, and documented a 10 to 20-fold higher affinity of ACE2 for SARS-CoV-2 compared to …
receptor of human pathogenic coronaviruses [severe acute respiratory syndrome
coronavirus (SARS-CoV), HCoV-NL63, and SARSCoV-2 (COVID-19)], and it plays a crucial
role in the entry of virus into the cell to cause the final infection (1). Wrapp and colleagues
recently provided the Cryo-EM structure of the virus spike protein, the known ligand for
ACE2, and documented a 10 to 20-fold higher affinity of ACE2 for SARS-CoV-2 compared to …