COX-2 plays a role in angiogenic DBA+ uNK cell subsets activation and pregnancy protection in LPS-exposed mice
B Zavan, EM De Almeida, ÉSL Salles… - Placenta, 2016 - Elsevier
Abstract Introduction Although uterine Natural Killer (uNK) cells have cytoplasmic granules
rich in perforin and granzymes, these cells do not degranulate in normal pregnancy. DBA
lectin+ uNK cells produce angiogenic factors which stimulate remodeling of uterine
arterioles to increase blood flow within the growing feto-placental unit. We sought to
investigate the importance of COX-2 on mouse pregnancy inoculated with Gram-negative
bacteria Lipopolysaccharide (LPS) by treating with a selective COX-2 inhibitor (nimesulide) …
rich in perforin and granzymes, these cells do not degranulate in normal pregnancy. DBA
lectin+ uNK cells produce angiogenic factors which stimulate remodeling of uterine
arterioles to increase blood flow within the growing feto-placental unit. We sought to
investigate the importance of COX-2 on mouse pregnancy inoculated with Gram-negative
bacteria Lipopolysaccharide (LPS) by treating with a selective COX-2 inhibitor (nimesulide) …
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