[PDF][PDF] CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: a pilot study
Int Angiol, 2010•academia.edu
Aim. We previously reported unexpectedly robust associa-tions between vascular
haemodynamic (VH) anomalies in the principal extracranial cerebral veins, causing chronic
cerebrospinal venous insufficiency (CCSVI), and multiple sclerosis (MS). Aim of this study
was to investigate the relationship between the VH changes and MRI measures of MS
disease severity in a cross sectional survey. Methods. The number of anomalous VH criteria
were mea-sured using an echo-color Doppler, whereas CSF flow, atrophy and lesion …
haemodynamic (VH) anomalies in the principal extracranial cerebral veins, causing chronic
cerebrospinal venous insufficiency (CCSVI), and multiple sclerosis (MS). Aim of this study
was to investigate the relationship between the VH changes and MRI measures of MS
disease severity in a cross sectional survey. Methods. The number of anomalous VH criteria
were mea-sured using an echo-color Doppler, whereas CSF flow, atrophy and lesion …
Aim. We previously reported unexpectedly robust associa-tions between vascular haemodynamic (VH) anomalies in the principal extracranial cerebral veins, causing chronic cerebrospinal venous insufficiency (CCSVI), and multiple sclerosis (MS). Aim of this study was to investigate the relationship between the VH changes and MRI measures of MS disease severity in a cross sectional survey.
Methods. The number of anomalous VH criteria were mea-sured using an echo-color Doppler, whereas CSF flow, atrophy and lesion measures were obtained from quantitative magnetic resonance imaging (MRI) analysis in sixteen consecutive relapsing-remitting MS patients,(mean age: 36.1±SD 7.3 years, disease duration: 7.5±1.9 years and median EDSS: 2.5) and in 8 healthy controls (HC) with similar age and sex distributions.
Results. All 16 MS patients investigated and none of the
HCs met the VH criteria for CCSVI (P< 0.0001). MS patients showed significantly lower net CSF flow compared to the HC (P= 0.038) that was associated with number of anomalous VH criteria present (r= 0.79, P< 0.001). Moreover, increases in the number of anomalous VH criteria present were negatively associated with lower whole brain volume (Spearman R=-0.5, P= 0.05).
Conclusion. VH changes occur more frequently in MS patients than controls. Altered VH is associated with abnormal CSF flow dynamics and decreased brain volume.
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