Repeated Ca2+ depletion and repletion of short duration, termed Ca2+ preconditioning
(CPC), is hypothesized to protect the heart from lethal injury after exposing it to the Ca2+
paradox (Ca2+ PD). Hearts were preconditioned with five cycles of Ca2+ depletion (1
minute) and Ca2+ repletion (5 minutes). These hearts were then subjected to Ca2+ PD, ie,
one cycle of Ca2+ depletion (10 minutes) and Ca2+ repletion (10 minutes). Hearts subject to
the Ca2+ PD underwent rapid necrosis, and myocytes were severely injured. CPC hearts …

Ca^<2+> preconditioning elicits a unique protection against the Ca^<2+> paradox injury in
rat heart : role of adenosine | CiNii Research … Ca^<2+> preconditioning elicits a unique
protection against the Ca^<2+> paradox injury in rat heart : role of adenosine …