Myosin 5a is a two-headed actin-dependent motor that transports various cargoes in cells.
Its enzymology and mechanochemistry have been extensively studied in vitro. It is a
processive motor that takes multiple 36nm steps on actin. The enzymatic activity of myosin 5
is regulated by an intramolecular folding mechanism whereby its lever arms fold back
against the coiled-coil tail such that the motor domains directly bind the globular tail
domains. We show that the structure seen in individual folded molecules is consistent with …

Myosin 5a is a two-headed actin-dependent motor that transports various cargoes in cells.
Its enzymology and mechanochemistry have been extensively studied in vitro. It is a
processive motor that takes multiple 36 nm steps on actin. The enzymatic activity of myosin 5
is regulated by an intramolecular folding mechanism whereby its lever arms fold back
against the coiled-coil tail such that the motor domains directly bind the globular tail
domains. We show that the structure seen in individual folded molecules is consistent with …