Leishmania parasites have evolved a number of strategies to cope with the harsh
environmental changes during mammalian infection. One of these mechanisms involves the
functional gain that allows mitochondrial 2-Cys peroxiredoxins to act as molecular
chaperones when forming decamers. This function is critical for parasite infectivity in
mammals, and its activation has been considered to be controlled exclusively by the enzyme
redox state under physiological conditions. Herein, we have revealed that magnesium and …