Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis …
Imbalance in metal ion homeostasis is a hallmark in neurodegenerative conditions involving
protein deposition, and amyotrophic lateral sclerosis (ALS) is no exception. In particular, Ca
2+ dysregulation has been shown to correlate with superoxide dismutase-1 (SOD1)
aggregation in a cellular model of ALS. Here we present evidence that SOD1 aggregation is
enhanced and modulated by Ca 2+. We show that at physiological pH, Ca 2+ induces
conformational changes that increase SOD1 β-sheet content, as probed by far UV CD and …
protein deposition, and amyotrophic lateral sclerosis (ALS) is no exception. In particular, Ca
2+ dysregulation has been shown to correlate with superoxide dismutase-1 (SOD1)
aggregation in a cellular model of ALS. Here we present evidence that SOD1 aggregation is
enhanced and modulated by Ca 2+. We show that at physiological pH, Ca 2+ induces
conformational changes that increase SOD1 β-sheet content, as probed by far UV CD and …