Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced
tumors in laboratory rodents while increasing mean and maximum life spans. It has been
suggested that CR extends longevity and reduces age-related pathologies by reducing the
levels of DNA damage and mutations that accumulate with age. This hypothesis is attractive
because the integrity of the genome is essential to a cell/organism and because it is
supported by observations that both cancer and immunological defects, which increase …

Caloric restriction (CR) without malnutrition is the only experimental manipulation that has
consistently been shown to increase the mean and maximum lifespan of laboratory rodents.
It has been suggested that CR extends the longevity of rodents and reduces the incidence of
age-related pathological lesions by reducing the levels of DNA damage and mutations that
accumulate with age within a cells genome. This hypothesis is attractive because the
integrity of the genome is essential to a cell/organism and because it is supported by the …