[PDF][PDF] Cancer-associated fibroblast–secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas
S Tripathi, H Najem, C Dussold… - Journal of Clinical …, 2024 - Am Soc Clin Investig
… We had initially hypothesized that collagen might serve as a physical barrier to immune
surveillance. Instead, we found CD11c+ immune cells embedded in collagen. LAIR1+
immune cells were found to be enriched in regions of collagen, indicating a potentially
previously unappreciated mechanism of glioma-mediated immune suppression (Figure 1I).
Currently, there is a phase I trial of a LAIR1 antagonist in myeloid malignancies (NextCure
NCT05787496) that could be considered as a new treatment for …
surveillance. Instead, we found CD11c+ immune cells embedded in collagen. LAIR1+
immune cells were found to be enriched in regions of collagen, indicating a potentially
previously unappreciated mechanism of glioma-mediated immune suppression (Figure 1I).
Currently, there is a phase I trial of a LAIR1 antagonist in myeloid malignancies (NextCure
NCT05787496) that could be considered as a new treatment for …