The tuberculosis (TB) pandemic demands urgent interventions such as those designed to
interrupt Mycobacterium tuberculosis (Mtb) transmission, a challenge exacerbated by our
poor understanding of the events enabling successful transfer of infectious bacilli between
hosts. To address this problem, we developed the Respiratory Aerosol Sampling Chamber
(RASC), a personal clean-room equipped with high-efficiency filtration and sampling
technologies that allow biosafe capture and isolation of particulate matter–including Mtb …