Background: The natriuretic peptides play an important role in salt homeostasis and blood
pressure regulation. It has been suggested that obesity promotes a relative natriuretic
peptide deficiency, but this has been a variable finding in prior studies and the cause is
unknown. Aim: The aim of this study was to examine the association between obesity and
natriuretic peptide levels and evaluate the role of hyperinsulinemia and testosterone as
mediators of this interaction. Methods: We studied 7770 individuals from the Framingham …

Cardiac natriuretic peptides, obesity, and insulin resistance : evidence from two community-based
studies | CiNii Research … Cardiac natriuretic peptides, obesity, and insulin resistance :
evidence from two community-based studies …