Caspase-mediated apoptosis and cell death of rhesus macaque CD4+ T-cells due to cryopreservation of peripheral blood mononuclear cells can be rescued by …
Cryopreservation of peripheral blood mononuclear cells (PBMC) from animal model studies
and clinical trials is utilized as a primary method for long-term storage of PBMC for future in
vitro and in vivo applications. The objective of this study was to define the mechanistic
pathways involved in cryopreservation-induced apoptosis of CD4+ T-cells in PBMC, and to
evaluate a cytokine treatment of the cryopreserved samples to rescue apoptosis for the
potential future use of the cryopreserved PBMC. Using cryopreserved PBMC samples …
and clinical trials is utilized as a primary method for long-term storage of PBMC for future in
vitro and in vivo applications. The objective of this study was to define the mechanistic
pathways involved in cryopreservation-induced apoptosis of CD4+ T-cells in PBMC, and to
evaluate a cytokine treatment of the cryopreserved samples to rescue apoptosis for the
potential future use of the cryopreserved PBMC. Using cryopreserved PBMC samples …
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