Catalytic enantioselective alkylation of sulfenate anions to chiral heterocyclic sulfoxides using halogenated pentanidium salts
We report halogenated pentanidiums as phase‐transfer catalysts for the asymmetric
alkylation of sulfenate anions to various sulfoxides with high enantioselectivities (up to 99%
ee) and yields (up to 99%). This approach gives access to enantioenriched heterocyclic
sulfoxides that might not be compatible with strong oxidants or organometallic reagents.
Computational studies have revealed that the multiple noncovalent interactions such as
halogen bonds and nonclassical hydrogen bonds are involved.
alkylation of sulfenate anions to various sulfoxides with high enantioselectivities (up to 99%
ee) and yields (up to 99%). This approach gives access to enantioenriched heterocyclic
sulfoxides that might not be compatible with strong oxidants or organometallic reagents.
Computational studies have revealed that the multiple noncovalent interactions such as
halogen bonds and nonclassical hydrogen bonds are involved.
Abstract
We report halogenated pentanidiums as phase‐transfer catalysts for the asymmetric alkylation of sulfenate anions to various sulfoxides with high enantioselectivities (up to 99 % ee) and yields (up to 99 %). This approach gives access to enantioenriched heterocyclic sulfoxides that might not be compatible with strong oxidants or organometallic reagents. Computational studies have revealed that the multiple noncovalent interactions such as halogen bonds and nonclassical hydrogen bonds are involved.
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