Caveolin-1 knockout mice exhibit airway hyperreactivity
B Aravamudan, SK VanOosten… - … of Physiology-Lung …, 2012 - journals.physiology.org
Caveolae are flask-shaped plasma membrane invaginations expressing the scaffolding
caveolin proteins. Although caveolins have been found in endothelium and epithelium
(where they regulate nitric oxide synthase activity), their role in smooth muscle is still under
investigation. We and others have previously shown that caveolae of human airway smooth
muscle (ASM), which express caveolin-1, contain Ca2+ and force regulatory proteins and
are involved in mediating the effects of inflammatory cytokines such as TNF-α on …
caveolin proteins. Although caveolins have been found in endothelium and epithelium
(where they regulate nitric oxide synthase activity), their role in smooth muscle is still under
investigation. We and others have previously shown that caveolae of human airway smooth
muscle (ASM), which express caveolin-1, contain Ca2+ and force regulatory proteins and
are involved in mediating the effects of inflammatory cytokines such as TNF-α on …
CAVEOLIN-1 KNOCK OUT MICE EXHIBIT AIRWAY HYPERREACTIVITY 3
GC Thompson, YS Prakash, CM Pabelick - 2012 - journals.physiology.org
Caveolae are flask-shaped plasma membrane invaginations expressing the scaffolding
caveolin 27 proteins. While caveolins have been found in endothelium and epithelium
(where they regulate nitric 28 oxide synthase activity), their role in smooth muscle is still
under investigation. We and others have 29 previously shown that caveolae of human
airway smooth muscle (ASM; which express caveolin-1) 30 contain Ca2+ and force
regulatory proteins, and are involved in mediating the effects of inflammatory 31 cytokines …
caveolin 27 proteins. While caveolins have been found in endothelium and epithelium
(where they regulate nitric 28 oxide synthase activity), their role in smooth muscle is still
under investigation. We and others have 29 previously shown that caveolae of human
airway smooth muscle (ASM; which express caveolin-1) 30 contain Ca2+ and force
regulatory proteins, and are involved in mediating the effects of inflammatory 31 cytokines …
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