Cavity formation and preferential interactions in urea solutions: Dependence on urea aggregation
S Weerasinghe, PE Smith - The Journal of chemical physics, 2003 - pubs.aip.org
The properties of urea solutions are of considerable interest in understanding how urea
denatures most proteins. 1, 2 Many experimental3–9 and theoretical10–15 studies have
focused on determining the variation in urea and water aggregation or structure with urea
concentration in an effort to relate these changes to the corresponding denaturation effects.
Different conclusions concerning the ability of urea to promote water structure are found
depending on the technique used see Ref. 16 for a brief summary, with the prevailing view …
denatures most proteins. 1, 2 Many experimental3–9 and theoretical10–15 studies have
focused on determining the variation in urea and water aggregation or structure with urea
concentration in an effort to relate these changes to the corresponding denaturation effects.
Different conclusions concerning the ability of urea to promote water structure are found
depending on the technique used see Ref. 16 for a brief summary, with the prevailing view …
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