… Astrocyte activation occurs in response to diverse insults and plays a critical role in …
circadian clock protein BMAL1 regulates astrogliosis in a synergistic manner via a cell-autonomous …

… Functionally, loss of Bmal1 in astrocytes promotes … clock protein BMAL1 regulates astrocyte
activation and function in vivo, elucidating a novel mechanism by which the circadian clock …

… regions where circadian rhythms of glial cells, ie astrocytes, … of Bmal1 increases the level
of GFAP in a cell-autonomous … astrocyte activation (Schoknecht & Shalev, 2012). Since …

… cell-autonomous activation phenotype. We report here that astrocyte-specific deletion of
Bmal1 influences endolysosome function, autophagy, and protein degradation dynamics. In vitro…

… transcriptional activation by Clock/Bmal1 heterodimers, … ) genes through E-box regulatory
sequences. After dimerization … damps circadian rhythms of membrane potential and clock gene …

… cell-autonomous activation of astrocytes by deletion of the clock gene Bmal1, which induces
several activation … that deletion of Bmal1 globally disrupts Aβ interstitial fluid rhythms and …

… They observed that Bmal1 modulates distinct cell-autonomous transcriptional programs in …
suggest that the astrocytic circadian clock may regulate the activation and downstream genes …

… astrocyte circadian clock as … cell autonomous and regulates the ability of astrocytes to
support neuronal survival in vitro [54]. BMAL1 in astrocytes appears to mediate astrocyte activation …

… An important aspect of the circadian clock is that it is regulated in a tissue- … cell-autonomous
activation of astrocytes by deletion of the clock gene Bmal1, which induces several activation …

… and peripheral clocks and cell-autonomous oscillators within … In the ARC, the astrocyte
circadian clock might control food … which deletion of Bmal1 in astrocytes constantly elevates VIP …