Cellular response to moderate chromatin architectural defects promotes longevity
Changes in chromatin organization occur during aging. Overexpression of histones partially
alleviates these changes and promotes longevity. We report that deletion of the histone H3-
H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae.
This longevity effect was mediated through TOR signaling inhibition. We present evidence
for evolutionarily conserved transcriptional and phenotypic responses to defects in
chromatin structure, collectively termed the chromatin architectural defect (CAD) response …
alleviates these changes and promotes longevity. We report that deletion of the histone H3-
H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae.
This longevity effect was mediated through TOR signaling inhibition. We present evidence
for evolutionarily conserved transcriptional and phenotypic responses to defects in
chromatin structure, collectively termed the chromatin architectural defect (CAD) response …