Changes in PGC‐1α/SIRT1 signaling impact on mitochondrial homeostasis in amyloid-beta peptide toxicity model
JD Panes, PA Godoy, T Silva-Grecchi… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has
been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ
are not well understood. We studied the effects of AβOs on mitochondrial function and on
key proteins that regulate mitochondrial dynamics and biogenesis in hippocampal neurons
and PC-12 cells. We find that AβOs treatment caused a reduction in total Mfn1 after a 2 h …
impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has
been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ
are not well understood. We studied the effects of AβOs on mitochondrial function and on
key proteins that regulate mitochondrial dynamics and biogenesis in hippocampal neurons
and PC-12 cells. We find that AβOs treatment caused a reduction in total Mfn1 after a 2 h …