Changes in basement membrane components in an experimental model of skeletal muscle degeneration and regeneration induced by snake venom and myotoxic …
T Escalante, P Saravia-Otten, S Gastaldello… - Toxicon, 2021 - Elsevier
Skeletal muscle regeneration is impaired after myonecrosis induced by viperid snake
venoms, but the mechanisms behind such poor regenerative outcome are not fully
understood. This study compared the changes in basement membrane (BM) components in
mouse skeletal muscle in two different scenarios of muscle injury:(a) injection of Bothrops
asper venom, as a model of poor regeneration, and (b) injection of a myotoxic fraction (Mtx)
isolated from this venom, as a model of successful regeneration. The degradation and …
venoms, but the mechanisms behind such poor regenerative outcome are not fully
understood. This study compared the changes in basement membrane (BM) components in
mouse skeletal muscle in two different scenarios of muscle injury:(a) injection of Bothrops
asper venom, as a model of poor regeneration, and (b) injection of a myotoxic fraction (Mtx)
isolated from this venom, as a model of successful regeneration. The degradation and …