Background Placental protein expression plays a crucial role during pregnancy. We
hypothesized that:(1) circulating levels of pregnancy-associated, placenta-related proteins
throughout gestation reflect the temporal progression of the uncomplicated, full-term
pregnancy, and can effectively estimate gestational ages (GAs); and (2) preeclampsia (PE)
is associated with disruptions in these protein levels early in gestation; and can identify
impending PE. We also compared gestational profiles of proteins in the human and mouse …

ABSTRACT 1 Background: Placental protein expression plays a crucial biological role
during normal and 2 complicated pregnancies. We hypothesized that:(1) circulating
pregnancy-associated, placenta-3 related protein levels throughout gestation reflect the
uncomplicated, full-term temporal 4 progression of human gestation, and effectively
estimates gestational ages (GAs);(2) 5 pregnancies with underlying placental pathology,
such as preeclampsia (PE), are associated with 6 disruptions in this GA estimation in early …