Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma
S Bernardi, C Zennaro, S Palmisano… - Journal of the Renin …, 2012 - journals.sagepub.com
Journal of the Renin-Angiotensin-Aldosterone System, 2012•journals.sagepub.com
Introduction: A new arm of the renin–angiotensin system (RAS) has been recently
characterized; this includes angiotensin converting enzyme (ACE) 2 and angiotensin (Ang)
1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-
7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to
characterize RAS expression in human colon adenocarcinoma and to investigate whether
Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells. Materials …
characterized; this includes angiotensin converting enzyme (ACE) 2 and angiotensin (Ang)
1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-
7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to
characterize RAS expression in human colon adenocarcinoma and to investigate whether
Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells. Materials …
Introduction: A new arm of the renin–angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and angiotensin (Ang)1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to characterize RAS expression in human colon adenocarcinoma and to investigate whether Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells.
Materials and methods: Gene, protein expression and enzymatic activity of the main components of the RAS were determined on non-neoplastic colon mucosa as well as on the tumor mass and the mucosa taken 5 cm distant from it, both collected from patients with colon adenocarcinoma. Two different human colon cancer cell lines were treated with AngII and Ang1-7.
Results: The novel finding of this study was that MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors. However, AngII and Ang1-7 did not have any pro-/antiproliferative effects in the cell lines studied.
Conclusions: The data suggest that upregulation of the MasR could be used as a diagnostic marker of colon adenocarcinoma.
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