Characterization of a secretory hydrolase from Mycobacterium tuberculosis sheds critical insight into host lipid utilization by M. tuberculosis
KH Singh, B Jha, A Dwivedy, E Choudhary… - Journal of Biological …, 2017 - ASBMB
Mycobacterium tuberculosis causes tuberculosis in humans and predominantly infects
alveolar macrophages. To survive inside host lesions and to evade immune surveillance,
this pathogen has developed many strategies. For example, M. tuberculosis uses host-
derived lipids/fatty acids as nutrients for prolonged persistence within hypoxic host
microenvironments. M. tuberculosis imports these metabolites through its respective
transporters, and in the case of host fatty acids, a pertinent question arises: does M …
alveolar macrophages. To survive inside host lesions and to evade immune surveillance,
this pathogen has developed many strategies. For example, M. tuberculosis uses host-
derived lipids/fatty acids as nutrients for prolonged persistence within hypoxic host
microenvironments. M. tuberculosis imports these metabolites through its respective
transporters, and in the case of host fatty acids, a pertinent question arises: does M …
Characterization of a secretory hydrolase from Mycobacterium tuberculosis sheds critical insight into host lipid utilization by M. tuberculosis
Mycobacterium tuberculosis causes tuberculosis in humans and predominantly infects
alveolar macrophages. To survive inside host lesions and to evade immune surveillance,
this pathogen has developed many strategies. For example, M. tuberculosis uses host-
derived lipids/fatty acids as nutrients for prolonged persistence within hypoxic host
microenvironments. M. tuberculosis imports these metabolites through its respective
transporters, and in the case of host fatty acids, a pertinent question arises: does M …
alveolar macrophages. To survive inside host lesions and to evade immune surveillance,
this pathogen has developed many strategies. For example, M. tuberculosis uses host-
derived lipids/fatty acids as nutrients for prolonged persistence within hypoxic host
microenvironments. M. tuberculosis imports these metabolites through its respective
transporters, and in the case of host fatty acids, a pertinent question arises: does M …