Characterization of the product of a nonribosomal peptide synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus terreus
Genome sequencing of the fungus Aspergillus terreus uncovered a number of silent core
structural biosynthetic genes encoding enzymes presumed to be involved in the production
of cryptic secondary metabolites. There are five nonribosomal peptide synthetase (NRPS)-
like genes with the predicted AT-TE domain architecture within the A. terreus genome.
Among the five genes, only the product of pgnA remains unknown. The Tet-on system is an
inducible, tunable and metabolism-independent expression system originally developed for …
structural biosynthetic genes encoding enzymes presumed to be involved in the production
of cryptic secondary metabolites. There are five nonribosomal peptide synthetase (NRPS)-
like genes with the predicted AT-TE domain architecture within the A. terreus genome.
Among the five genes, only the product of pgnA remains unknown. The Tet-on system is an
inducible, tunable and metabolism-independent expression system originally developed for …
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