Parkinson's disease's etiology is unknown, although evidence suggests the involvement of
oxidative modifications of intracellular components in disease pathobiology. Despite the
known involvement of the extracellular matrix in physiology and disease, the influence of
oxidative stress on the matrix has been neglected. The chemical modifications that might
accumulate in matrix components due to their long half-live and the low amount of
extracellular antioxidants could also contribute to the disease and explain ineffective cellular …

Parkinson's disease's etiology is unknown, although evidence suggests the involvement of
oxidative modifications of intracellular components in disease pathobiology. Despite the
known involvement of the extracellular matrix in physiology and disease, the influence of
oxidative stress on the matrix has been neglected. The chemical modifications that might
accumulate in matrix components due to their long half-live and the low amount of
extracellular antioxidants could also contribute to the disease and explain ineffective cellular …