Chemogenetic control of gene expression and cell signaling with antiviral drugs
We developed a method in which the NS3 cis-protease from hepatitis C virus can be used
as a ligand-inducible connection to control the function and localization of engineered
proteins in mammalian cells. To demonstrate the versatility of this approach, we designed
drug-sensitive transcription factors and transmembrane signaling proteins, the activities of
which can be tightly and reversibly controlled through the use of clinically tested antiviral
protease inhibitors.
as a ligand-inducible connection to control the function and localization of engineered
proteins in mammalian cells. To demonstrate the versatility of this approach, we designed
drug-sensitive transcription factors and transmembrane signaling proteins, the activities of
which can be tightly and reversibly controlled through the use of clinically tested antiviral
protease inhibitors.
Abstract
We developed a method in which the NS3 cis-protease from hepatitis C virus can be used as a ligand-inducible connection to control the function and localization of engineered proteins in mammalian cells. To demonstrate the versatility of this approach, we designed drug-sensitive transcription factors and transmembrane signaling proteins, the activities of which can be tightly and reversibly controlled through the use of clinically tested antiviral protease inhibitors.
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